A study of amygdaloid kindling in kittens.

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With a wish to understand the epileptic phenomenon in the immature brain, we compared the development of amygdaloid kindling in kittens with that in adult cats. Five kittens (kitten group) and six adult cats (adult group) were subjected to kindling preparation, and the results obtained were as follows: 1) Although the kindling rates between kitten and adult groups were similar, kittens reached kindling stage 4 quicker and remained longer at stages 4-5. To arrive at kindling stage 4, the kitten group needed significantly fewer stimulations and a shorter AD duration, after which many stimulations and a longer AD duration were needed to arrive at the final stage in comparison with the adult group.<BR>2) The GST of the kitten group was significantly higher than that of the adult group.<BR>From these results, we were able to conclude that the excitatory system should be stronger than the inhibitory system of the kitten limbic structure, whereas the inhibitory system of the generalized epileptic mechanism should be stronger than the excitatory system in the kitten brain.
一般社団法人日本てんかん学会の論文