Aggregate morphology of peptide lipids having hydroxyl groups : Molecular basis for formation of inverted hexagonal, inverted cubic, bilayer, and micellar phases.
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概要
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Three types of peptide lipids having different numbers of hydroxyl groups in their head moieties, (HO)C<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I>, QC<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I> and Q<SUB>2</SUB>LysC<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I> (<I>n</I>=14, 16), were prepared, and their morphological behavior was investigated by various physical techniques: negative staining and freeze-fracture electron microscopy, low-angle X-ray diffraction, selected area electron diffraction, fluorescence polarization spectroscopy, and differential scanning calorimetry. QC<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I>, having four hydroxyl groups in the head moiety, underwent aggregation in the aqueous dispersion state to afford the nonbilayer phase, which was constituted with highly developed globular domains with face-centered cubic (C<SUB>II</SUB>) lattice, above the phase transition temperature (<I>T</I><SUB>m</SUB>). This C<SUB>II</SUB> phase was transformed into the bilayer one below <I>T</I><SUB>m</SUB>. On the other hand, Q<SUB>2</SUB>LysC<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I>, having eight hydroxyl groups in the head moiety, formed bilayer aggregates in a whole temperature range, above and below <I>T</I><SUB>m</SUB>. Deprotonation of the hydroxyl groups of QC<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I> and Q<SUB>2</SUB>LysC<SUB>5</SUB>Ala2C<I><SUB>n</SUB></I> resulted in morphological changes to afford the bilayer and micellar phases, respectively. Two-component lipid systems composed of (HO)C<SUB>5</SUB>Ala2C<SUB>14</SUB> and Q<SUB>2</SUB>LysC<SUB>5</SUB>Ala2C<SUB>14</SUB> at appropriate molar ratios afforded the inverted hexagonal (H<SUB>II</SUB>) phase in the aqueous dispersion state; the first example of the H<SUB>II</SUB> phase formed with artificial double-chain amphiphiles. The aggregate morphology was discussed on the basis of the critical packing mode of lipid molecules.
- 公益社団法人 日本化学会の論文
著者
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Murakami Yukito
Department Of Chemical Science And Technology Faculty Of Engineering Kyushu University
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KIKUCHI Jun-ichi
Department of Applied Chemistry, Faculty of Science and Engineering, Saga University
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Takaki Toshihiko
Department of Organic Synthesis, Faculty of Engineering, Kyushu University
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Uchimura Katsuya
Department of Organic Synthesis, Faculty of Engineering, Kyushu University
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