The Crystal and Molecular Structure of Bicyclomycin, a New Antibiotic
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概要
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The molecular structure of a new antibiotic, Bicyclomycin (C<SUB>12</SUB>H<SUB>18</SUB>O<SUB>7</SUB>N<SUB>2</SUB>), has been elucidated by X-ray diffraction analysis. Bicyclomycin crystallizes from aqueous solution in two forms, an orthorhombic and a monoclinic systems. The crystal data for the former are <I>a</I>=11.72, <I>b</I>=12.72, <I>c</I>=8.80 Å and the space group P2<SUB>1</SUB>2<SUB>1</SUB>2<SUB>1</SUB>, while those for the latter are <I>a</I>=10.27, <I>b</I>=10.91, <I>c</I>=6.67 Å, β=101.4°, and the space group P2<SUB>1</SUB> The crystal structure of the former was solved by the direct method and refined by least-squares method to a final <I>R</I> factor of 0.07 for 1623 reflections. The established structure is<BR>(<U>Remark: Graphics omitted.</U>)<BR>The diketopiperazine ring is folded into a boat form. The conformations of the side chain are all <I>gauche</I> or nearly so. All the oxygen and nitrogen atoms participate in two intramolecular and four intermolecular hydrogen bonds.
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