経口脂肪負荷後の肥満者血中脂質, IRI HGHの推移及び, IRI分画の研究

概要

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Plasma samples were obtained from 7 normal and 5 obese subjects (greater than 150% of ideal body weight) every 30 to 60 minutes for 5 hours after oral administration of butter (1 g/kg). Plasma lipids, IRI (immunoreactive insulin), HGH (human growth hormone) were examined and components of the plasma IRI were characterized by gel filtration on Sephadex G-50, fine, equilibrated in 1 M acetic acid.<BR>In the fasting state, the obese had significantly higher levels of plasma triglyceride and free fatty acids than the normal, but after fat load the free fatty acids levels of the obese did not rise so rapidly as those of the normal did during 5 hours. HGH levels were not significantly different between the two groups. The obese had two significantly higher IRI peaks at 30 and 120 minutes.<BR>In terms of plasma "big" percent determined according to the method of Roth, the obese patients had higher fasting levels of proinsulin than the normal subjects.<BR>A considerable amount of degraded components appeared after the fat load. The patterns of "big" insulin/degraded components were quite different between the two groups.<BR>The significance of degraded components was discussed and a rapid turn over rate of proinsulin, including supply and degradation, was suggested.
日本内分泌学会の論文