卵胞発育機序に関する研究:I.FSH, LHおよびエストロゲンの卵胞発育に及ぼす影響

概要

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The effect of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estrogen on ovarian follicle growth was studied in hypophysectomized rats using the histologic technique.<BR>After the administration of FSH to hypophysectomized immature female rats, many growing follicles of different sizes were observed. In particular, there was an increase in the number of large growing follicles with a thickening of the theca layer. Moreover, the administration of FSH caused many follicles to induce antrum or cavity formation. Although the administration of LH resulted in the repair of interstitial cells, there was no resulting follicle growth. On the other hand, the administration of estrogen caused small follicles to develop into medium-sized follicles with multi layers of granulosa cells, containing a large number of mitoses but no antrum.<BR>In effect, the administration of both FSH and estrogen caused some follicles to grow, but it seemed possible that the follicle growth after the administration of FSH differed in character from that after the administration of estrogen. Thus, it might be concluded that FSH stimulates the maturation rather than the growth of the follicle.
日本内分泌学会の論文