Glucocorticoidの抗ショック作用の研究:第I報 : Dexamethasoneのエステル型による抗エンドトキシン効果の相異
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There have been controversial discussions as to the effectiveness of glucocorticoid treatment for various shock states, although more than a decade has passed since pharmacological doses of glucocorticoid was begun to be used for the treatment of various shock states. We have tried to investigate the anti-shock mechanism of glucocorticoids, and firstly we compared the anti-endotoxic potency of dexamethasone based on different ester types in mice.<BR>Dexamethasone disodium phosphate (MD-P) and dexamethasone sodium sulfate (DM-S) were compared. Each steroid was diluted to 0.2 mg/ml with saline calculated as dexamethasone and administered intraperitoneally to mice. After intervals of 0, 1, 2, 3, 6, 12 and 24 hours, 0.5 mg of endotoxin (E-coli; 0127-B8, Difco, USA) was injected intraperitoneally, and the survival rates were calculated 72 hours later.<BR>In the control group the survival rate was 20.4%. In the group administered DM-P, the survival rates were 65.0% initially, 57.1% after 1 hour, 45.7% after 2 hours, 25.0% after 3 hours, 25.0% after 6 hours, 15.0% after 12 hours and 16.6% after 24 hours. On the other hand, in the group administered DM-S the survival rates were 25.0%, 4.7%, 0%, 3.7%, 15.0%, 15.0% and 16.0% respectively. The groups pre-treated with DM-P at intervals of 0, 1 and 2 hours and pre-treated with DM-S at interval of 2 hours, exhibited a statistically significant difference in survival rates.<BR>We speculate that these differences in anti-endotoxic potency are due to its rate and speed on the liberation of free steroids from their ester types in blood. This means that glucocorticoid will manifest its anti-endotoxic potency depending on its concentration of free form in blood.
- 一般社団法人 日本内分泌学会の論文
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関連論文
- Glucocorticoidの抗ショック作用の研究:第2報 : Dexamethasoneの抗エンドトキシン効果と血中濃度-エステル型間における比較
- Glucocorticoidの抗ショック作用の研究:第I報 : Dexamethasoneのエステル型による抗エンドトキシン効果の相異