ACTH, インスリン低血糖, デキサメサゾンおよびメチラポンに対するcortiCoSteroneの分泌反応:特にcortisolとの関連について

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概要

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• Unlike cortisol, little is known about the role of corticosterone in man. In this study the effects of exogenous and endogenous ACTH, dexamethasone and metyrapone on the secretion of corticosterone and cortisol in healthy subjects were evaluated. Plasma corticosterone and cortisol levels were measured utilizing the specific radioimmunoassay techniques already reported by this laboratory.<BR>The results were as follows : <BR>1. Following the intramuscular administration of β<SUP>1-24</SUP>ACTH in doses of 0.06, 0.13, 0.25 and 0.5 mg at 0900, plasma corticosterone increased to 3.03, 4.67, 4.96 and 4.68 times (mean) as much as basal levels respectively, whereas plasma cortisol increased to 1.70, 1.79, 2.06 and 2.39 times. The rate of corticosterone secretion was higher than that of cortisol in response to exogenous ACTH, and the secretion of corticosterone was induced more rapidly than that of cortisol.<BR>2. Following the single intravenous administration of regular insulin (0.1 U/kg) at 0900, plasma corticosterone increased to 2.3-6.6 times as much as basal levels, whereas plasma cortisol increased to 1.4 - 3.0 times. Endogenous ACTH stimulated the secretion of corticosterone more effectively than it did that of cortisol.<BR>3. Four hours after the oral administration of dexamethasone in doses of 0.25, 0.5, 1.0 and 2.0 mg at 0900, plasma corticosterone decreased to 36.2, 29.7, 37.3 and 33.2% (mean) of basal levels respectively, whereas plasma cortisol decreased to 28.2, 23.6, 14.0 and 19.5% of basal levels. Plasma corticosterone was markedly suppressed by the administration of a small dose (0.25 mg) as well as by a large dose (2.0 mg) of dexamethasone, but plasma corticosterone revealed weaker suppressibility by dexamethasone than did plasma cortisol.<BR>4. Following the oral administration of metyrapone (750 mg) at 0900, the maximum reduction of their plasma corticosterone levels (2.8-4.6 ng/ml) was obtained at one hour later in six out of eight healthy subjects, and maximum reduction to 4.2 ng/ml was noted at two hours later in one healthy subject. After the metyrapone administration, no reduction in plasma corticosterone was noted in one healthy subject. While plasma cortisol levels decreased markedly at one or two hours after the metyrapone administration in all cases, plasma corticosterone levels in healthy subjects responded more poorly to metyrapone than did plasma cortisol levels.<BR>These results suggest that corticosterone secretion might be controlled by some different mechanism from that of cortisol secretion in man.

• 一般社団法人 日本内分泌学会の論文

著者

• 松村 茂一

  川崎医科大学内分泌内科

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• ACTH, インスリン低血糖, デキサメサゾンおよびメチラポンに対するcortiCoSteroneの分泌反応:特にcortisolとの関連について

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