甲状腺機能亢進症ならびに低下症における血中c-AMP, c-GMP濃度

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There have been few reports about the concentrations of plasma cAMP and cGMP in patients with hyper- and hypothyroidism. The aim of this study is to describe the concentrations of these plasma nucleotides and to discuss the relationship between plasma nucleotide levels and the concentrations of serum thyroid hormones and TSH in these patients. Four hundreds and eleven serum samples were obtained from 307 outpatients, 137 of them were from patients with Graves' disease and the rest from chronic thyroiditis. The patients with Graves' disease were divided into four groups; 19 samples from untreated patients (group I), 37 from treated patients with still elevated thyroid hormone levels (group II), 64 from treated patients with normal thyroid hormone levels (group III), and 17 from patients during remission (group IV). The patients with chronic thyroiditis were divided into two groups, 57 samples from untreated patients with hypothyroidism (group V) and 217 from patients with normal concentrations of serum thyroid hormones (group VI). Plasma cAMP, cGMP, T3, T4, TSH and thyroglobulin (Tg) were measured by RIAs. The concentrations of plasma cAMP of groups I, II, III, IV, V and VI were 38.73 ± 9.22 pmol/ml (mean ± SD), 36.52 ± 15.78, 33.90 ± 10.90, 32.99 ± 10.31, 38.07 ± 7.08 and 38.97 ± 8.13, respectively. They were clearly higher than that of normal subjects (23.08 ± 3.47, n=10). The concentrations of plasma cGMP of groups I, II, III, IV, V and VI were 6.41 ± 2.02 pmol/ml (mean ± SD), 4.39 ± 1.35, 4.92 ± 2.30, 4.40 ± 1.50, 5.46 ± 2.93 and 4.70 ±2.30, respectively. These values were not significantly different from those of the normal controls (5.80 ± 2.08, n= 10). There was no significant correlation between the concentrations of plasma cAMP and those of T3, T4, TSH as well as Tg in each group. However, significant positive correlations were found between the concentrations of cGMP and T3 in group I, and TSH in group V. Their linear regression coefficiencies were 0.479 (p<0.05) and 0.336 (p<0.025), respectively. A TRH stimulation test was carried out on 16 patients with chronic thyroiditis (TSH>10). A significant change was not observed in the concentrations of plasma cAMP, however, the concentrations of cGMP significantly decreased from 5.74 ± 2.04pmola (mean ± SD) to 3.53 ± 1.25 at 120 min after injection of TRH. In summary 1) The concentrations of plasma cAMP were significantly elevated in the outpatients with thyroid dysfunction. 2) The concentrations of plasma cGMP were correlated with those of serum triiodothyronine in untreated patients with Graves' disease and with those of serum TSH in untreated patients with hypothyroidism. 3) TRH reduced plasma cGMP levels in patients with chronic thyroiditis.
日本内分泌学会の論文

甲状腺機能亢進症ならびに低下症における血中c-AMP, c-GMP濃度

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