高LH・正プロラクチン性排卵障害に対するBromocriptineの効果

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It is well known that an acute administration of Bromocriptine (dopamine agonist) suppresses the serum LH level either in normal women or in women with polycystic ovary syndrome, in whom the serum LH level is elevated. The present study was carried out to examine the effectiveness of Bromocriptine on anovulatory women with a high LH level (serum LH>30 mIU/ml). Bromocriptine was administered for 3 months, 5 mg daily, to 9 anovulatory women with euprolactinemia (serum PRL<25 ng/ml). Ovulation was observed by their BBT charts. Before and after the treatment of Bromocriptine, FSH, LH and PRL secreting capacities were tested by LHRH and TRH injection. Also, estrone, estradiol and testosterone levels were measured before and after the Bromocriptine administration.<BR>Resting levels of LH, FSH and PRL were 45.4 ± 11.0 mIU/ml, 11.4 ± 3.0 mIU/ml, and 14.3 ± 4.7 ng/ml (M ± SD), respectively, before the treatment. As a result of the treatment, the LH level was markedly decreased to 27.3 ± 14.5 (M ± SD, PC0.05), and PRL decreased to 3.76 ± 4.2 ng/ml (M ± SD, P<0.005). On the other hand, FSH did not show a marked change. The responsiveness of LH to LHRH before the treatment showed a marked increase, which was suppressed by Bromocriptine. However, FSH showed no change. The responsiveness of PRL to TRH was suppressed by Bromocriptine. Serum estrone, estradiol and testosterone levels before the treatment were 115.5 ± 76.7 pg/ml, 93.7 ± 61.0 pg/ml and 0.809 ± 0.209 ng/ml (M ± SD), respectively, which showed no significant change after the treatment. Six cases out of 9 ovulated with Bromocriptine.<BR>From these results, it was concluded that 1) Bromocriptine induces ovulation in anovulatory women with a high LH level and euprolactinemia. 2) the underlying mechanismexists on the LH suppressive effect of Bromocriptine, which is independent of the PRL suppressive effect of Bromocriptine.
一般社団法人日本内分泌学会の論文

高LH・正プロラクチン性排卵障害に対するBromocriptineの効果

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