心内膜側冠微小血管における拍動パターン

概要

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In twelve open-chest anesthetized pigs, we used a portable needle-probe videomicroscope with a CCD camera to visualize phasic pattern of internal diameter on the subendocardial microvessels. Subendocardial arteriolar diameter decreased by 24±6% (p<0.001, n=13) and venular diameter decreased by 17±4% from end-diastole to end-systole (p<0.001, n=15). In contrast, the diameter of subepicardial arterioles was almost unchanged (2% decrease, n=5, p<0.01) and the venular diameter increased by 19% (n=8, p<0.001) from end-diastole to end-systole. There was a significant correlation between diameter in end-diastole and percent change in diameter from end-diastole to end-systole for subendocardial arterioles and venules (r=0.82 and 0.63, both: p<0.05). In conclusion, using a newly microscope system, we were able to observe the subendocardial vessels in diastole and systole. The vascular compression by cardiac contraction decreased the diameters of subendocardial arterioles and venules by about 20%, whereas subepicardial arterial diameter changed very little during the cardiac cycle and subepicardial venules increased in diameter during systole.