性ホルモンの血液レオロジー的性状に及ぼす影響

概要

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In the second trimester of normal pregnancy, whole blood viscosity decreases and red cell filterability significantly reduces compared with non-pregnant control. In order to elucidate these mechanisms, sex steroids were administered to female castrated rats and their effects on hemorheology were examined. Eighty castrated rats of Wistar strain were assigned to the following 4 groups-; E-group administered with 1mg of estradiol dipropionate, P-group administered with 24mg of hydroxyprogesterone caproate, EP-group administered with 1mg of estradiol dipropionate and 6mg of hydroxyprogesterone caproate and C-group (control) administered with 0.2ml of olive oil. Whole blood viscosities measured at a shear rate of 0.5 sec-1 by Contraves Low Shear viscometer and at a shear rate of 230 sec-1 by Wells-Blookfield viscometer significantly decreased in E-group and increased in P-group as compared with C-group. Hematocrit decreased significantly in E-group and increased in P-group. Red cell filterability was significantly lower in EP- and C-groups than those in E-and P-groups. From these results, it is suggested that the decrease in blood viscosity in normal human pregnancy is affected by estrogen and the decrease in red cell filterability during pregnancy is due to the effects of both estrogen and progesterone. (J. Jpn. Soc. Biorheol., 1 (2), 104~109, 1987).
特定非営利活動法人日本バイオレオロジー学会の論文