副甲状腺の神経体液性調節:迷走神経切断及びアトロピンの影響について

概要

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In order to elucidate the role of autonomic nervous system on the regulation of parathyroid function, the oxalate tolerance test was performed in normal, thyroparathyroidectomized, vagtomized and atropinized dogs. Plasma or serum samples were obtained to determine the total calcium content before, immediately after and up to 6 hours following a 30 minutes infusion of 40 mg/kg 0.4% sodium oxalate solution in physiological saline. The recovery was significantly faster in dogs bilaterally vagotomized than in intact animals. Similarly accelerated recovery was also observed in animals in which one of the 3 groups of original rootlets of the accessory nerve (AH rootlets of Okinaka), which later joins the vagus, was bilaterally sectioned intracranially immediately after their departure from the medulla oblongata. Administration of atropine during the test period also resulted in an accelerated recovery. In thyroparathyroidectomized, thyroparathyroidectomized-vagotomized and thyroparathyroidectomized-atropinized dogs the recovery was apparently retarded. Acceleration of the recovery from hypocalcemia approximately paralleled the dose of parathyroid hormone in thyroparathyroidectomized dogs.
日本内分泌学会の論文