甲状腺ホルモン代謝に及ぼすインシュリンの影響に関する実験的研究

スポンサーリンク

概要

• 論文の詳細を見る

• The experimental studies were made on interaction between thyroid hormone and insulin, especially concerning hormone balance. <BR>The results are summarized as follows : When a large dose of insulin was injected into rabbits, the thyroid gland's reaction to inhibit the hypoglysemic effect of insulin action, was spontaneous. Naturally, adrenocortic-, adrenomedullar- or anterior pituitary-hormone played the role, but thyroidhormone also reacted as one of the anti-insulin factors. This was suggested by the fact that this restoring power of thyroid was most strong in normal, retarded in alloxanized diabetic, and slight in thyroidectomized rabbits. <BR>Reacting mode of thyroid to insulin-injection was as follows : <BR>1. Thyroid-hormone, already existing in tissues and blood, reacts and metabolized first (at 3 and 6 hours, increased PBI, decreased BEI and increased its metabolites chemically and chromatographic-ally measured). <BR>During this time, the thyroid-gland itself also releases the rapid acting substances parallel T<SUB>3</SUB>, its related compounds (at 3 and 6 hours increased PBI<SUP>131</SUP>, T<SUB>3</SUB> and not identified substances in chromaiogramm). <BR>Then the thyroid gradually releases the thyroxine to restore the unbalance which occured after the injection of large dose of insulin (at 24 hours increased T<SUB>4</SUB>, chemically and chromatographically measured, and increased synthesis of it in the thyroid homogenate). <BR>2) In thyroidectomized-animals, injected T<SUP>4</SUP>-I<SUP>131</SUP> more rapidly metabolized than controls, when insulin was injected. <BR>3) In alloxanized-diabetic animals, the changes of thyroid-function above mentioned, were not only slighter than those of normal, but also their abnormalities were restored to normal by insulin injection. <BR>4) “In vitro” studies on rat liver-, muscle (diaphragm) and kidney slices, using Warburg apparatus, showed that in diaphragms, added insulin accelerates the promoting action of O<SUB>2</SUB>, consumptionsrate of thyroxine, and adsorption of T<SUB>4</SUB>-I<SUP>131</SUP> and its deiodination by the tissues. Namely, it suggested that the added insulin into incubation medium promoted thyroxine-I<SUP>131</SUP> utilization by the diaphragm.

• 日本内分泌学会の論文

著者

• 山崎 孝夫

  京都府立医大 吉田内科

関連論文

• Chloro-2-4-disulphamyl-toluene (Diurex) の使用経験 : 第11回日本循環器学会近畿地方学会総会
• 蛋白同化ホルモンの腎疾患に及ぼす影響 : 第10回日本循環器学会近畿地方学会総会
• ビタミンB1 (V.B1) 欠乏症に関する臨床実験的研究 : 第1編 V.B1欠乏症の発症実験
• 甲状腺ホルモン代謝に及ぼすインシュリンの影響に関する実験的研究
• 赤血球I131標識Triiodothyronine摂取率に依る甲状腺機能検査
• Idiopathic decrease in TBGの1症例について

スポンサーリンク