エストロゲンと脂質代謝:II エストロゲンの脂肪酸代謝に及ぼす影響について他の脱コレステロール剤と比較して

概要

論文の詳細を見る
In a previous paper, the author reported that the amount of urinary estrogen was found to be related to the serum lipid levels. The present paper deals with the effects of estradiol on the metabolism of carboxyl labeled fatty acid, comparing these effects with those of other anticholesterol drugs.<BR>1) In the estradiol-administered rats, the radioactivity of cholesterol ester in the serum was significantly decreased 2 hours after the injection and returned to normal 24 hours after the injection, while the radioactivity of cholesterol ester in the liver was increased 2 hours after the injection and a more significant increase was seen 24 hours later. Two hours after the injection, the serum phospholipid had showed a significantly increased radioactivity, which returned to normal 24 hours after the injection. The radioactivity of triglyceride in the serum was decreased 2 hours after the injection and returned to normal 24 hours after the injection.<BR>2) In the animals treated with triiodothyropropionic acid, the radioactivity of cholesterol ester in the serum and kidney was significantly decreased, while that of the liver remained within the normal range. The radioactivity of phospholipid and triglyceride in the serum and tissues seemed to be decreased.<BR>3) In the heparin or MER-29 administered rats, the radioactivity of lipids in the serum and tissues did not show any signficant changes.
日本内分泌学会の論文