Aldosteroneの化学的測定に関する臨床的研究:第1編測定法の吟味及び正常人の尿中Aldosterone排泄値について

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The determination method of urinary aldosterone by Hernando-Thorn, based on the Neher-Wettstein's method, was improved in such points as acidhydrolysis, extraction with Cohen type continuous extractor and colorimetry as standard of dl-aldosterone. The results obtained were as follows : 1) As 20 μg of dl-aldosterone free was added to urine of two normal adults persons respectively, the recovery of aldosterone by this method was 54.0% and 50.6%. 2) The urinary aldosterone determined on ten healthy adult persons, six males and four females, was between 2.0 and 12.0 μg per day, averaging 5.8±3.5 pg per day. 3) ACTH-Z of 20 units was intramuscularly administered for three consective days to four healthy adult persons, three males and a female, respectively, and then daily urinary aldosterone was measured in each case for three days before, during and immediately after the administration respectively. But, no increased urinary aldosterone excretion was confirmed in any case after ACTH-Z injection.
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