エストロン及びエストリオールの抗エストロゲン作用に関する研究
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概要
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It has been known that Estradiol (wich will be abbreviated as ED hereafter) is, chiefly, in the liver metabolized to Estrone (which will be hereafter abbreviated as EO), and to Estriol (which will be abbreviated as ET hereafter). It has also been assumed that both EO and ET were, merely, metabolites or final products of the process and that estrogenic effect was lower in the order of ED, EO and ET. For the purpose of to detect this non-specific effect of these Estrogens (which will be abbreviated as E. hereafter), Author has administered E to immature and mature spayed femal rats and has studied the effect on the weights of the uterus, adrenals, hypophysis and ovaries. These estragen compounds were given with or without mixing each others.<BR>The results are concluded as follows ;<BR>(1) Author has administered ED, EO and ET to rats without mixing each others and studied the weight gain of the uterus. Their effects were stronger in order of ED, EO and ET, but in the cases of administration of large doses of these estrogen compounds, there were no differences in gaining uterine weight. In the other words, irrespective of the doses of the estrogen compounds as are stated above, gain in uterine weight approach to certain limiting values.<BR>(2) The increase in weight of adrenals of the immature rats were more pronounced after they were administered ET compared with those after the administration of ED or EO. Also the weight gain of the hypophysis of the immature rats after administration of ET was observed. While the hypophysial weights were reduced after administration of large doses of EO and ED, they were, however, increased after administration of ET.<BR>(3) The effect on the uterine weight gain was more pronounced with the mixture of EO, ED and ET compared with single administration of ED. On the other hand, the mixtures appeared to prohibit the effect of ED in the range of 0.001 mg. to 1.0 mg. for the uterine weights gain of the mature spayed rats, at dosage of 1.0 mg for adrenal weights gain of mature spayed rats and at the dosage of 0.001 mg. for weights gain or immature rats' uterus.<BR>Author has shown that ED was the strongest estrogenic compounds and that, after ED has been metabolized to EO and ET, these metabolites might work as prohibiting agents against the effect of ED and also that they were not mere products of metabolism to be excreted for nothing. Author has also brought up the hypothesis that ET might have some stimulating effect on the hypophysis.
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