高血圧症とアルドステロン

概要

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Urinary aldosterone output in 44 cases of various hypertensive patients was estimated by a modification of Nowaczynski's method. The results showed that urinary aldosterone output was related proportionally to the grade of the occular fundi, the blood pressure and the duration of hypertension, and was not followed by reciprocal changes in urinary sodium and potassium excretion regularly, but was quite regularly in extracellular fluid volume.<BR>In the light of all findings described above, it seems to be proved beyond any doubt that the aldosterone secretion increased with the developement of arterial hypertnsion. This increased aldosterone secretion would be the main factor leading to an increased peripheral resistance and vascular reactivity of the arteriolar walls, accompanied with the expanded extracellular fluid volume and the changes of intra- and extracellular electrolytes. It is suggestive that the grade of arterial hypertension may become worse gradually by these changes.
日本内分泌学会の論文