糖尿病と高血圧との関係についての二, 三の実験的研究
スポンサーリンク
概要
- 論文の詳細を見る
Sixty-eight Wister-strain female rats, weighing around 70-80 grams, were used in the present experiment. (a) Both Skelton's adrenal regeneration hypertensive rats and Selye's DCA hypertensive rats were induced diabetic using alloxan 9 weeks after the first procedure to develop hypertension. (b) Alloxan diabetic rats were followed 9 weeks later by the Skelton's or Selye's procedures to develop hypertension. (c) Four groups of other experiments as illustrated in (6) were carried out. Measurement of the blood pressure was made in an interval of 7 days on all cases. All the rats were sacrificed 6 months later and were examined histo-pathologically. The following results were obtained.<BR>(1) Skelton's adrenal hypertensive rats, when they were alloxanized 9 weeks later, showed rapid, but temporal decline of the blood pressure and then showed its gradual elevation. The systolic blood pressure at the end of the experiment was 183±6 mmHg in average of 6 cases ; this value being 67 mmHg or 30 mmHg higher than that of normal rats (116±13 mmHg in average of 5 cases) or the adrenal regeneration hypertensive rats (153±7 mmHg in average of 6 cases). Various lesions, such as hypertrophy of the heart, sclerotic lesion of the kidney, thickness of the arterial walls of the heart, kidney, spleen and pancreas, and periarteritis nodosa of the mesenteric artery were more marked in this group of rats than in the Skelton's hypertensive rats.<BR>(2) Alloxan diabetic rats, were hypertensive by the technique of Skelton's adrenal regeneration 9 weeks later, showed marked and straight elevation of the blood pressure, having no tendency to decline. The systolic pressure was 214±11 mmHg in average of 6 rats at the end of the experiment. This value was 98 mmHg, 61 mmHg higher than that of normal rats, adrenal regeneration hypertensive rats respectively. Furthermore, the average blood pressure of this group was 31 mmHg higher than that of hypertensive rats followed with a alloxan diabetes. Hypertrophy of the heart, necrosis and scar formation in the heart muscle, sclerotic lesions in the kidney, thickness of the arterial walls in the heart, kidney, pancreas, and spleen, and periarteritis nodosa in the mesenteric artery were the most intensive in this group.<BR>(3) When DCA hypertensive rats were followed with alloxan diabetes, temporal decline of the blood pressure was observed and gradual elevation of the pressure was followed without signs of decline. The systolic pressure at the end of the experiment was 180±7 mmHg in average of 6 rats, being 20 mmHg higher than that of DCA hypertensive rats (159±5 mmHg in average of 3 rats). Marked hypertrophy of the heart and other lesions in the heart, kidney and spleen and blood vessels were observed, paralleling the degree of the elevation of the blood pressure.<BR>(4) Alloxan diabetic rats, when they were induced DCA hypertensive 9 weeks later, showed elevation of the blood pressure without a tendency of decline. The systolic pressure was 207±7 mmHg in average of 6 rats at the end of the experiment. This value was 91 mmHg, 44 mmHg, 27 mmHg higher than that of normal rats, DCA hypertensive rats, or DCA hypertensive rats followed with alloxanization, respectively. The lesions in the heart, kidney and blood vessels were the most intensive in this group of rats.<BR>(5) In rats involved by both diabetes and hypertension, preceded by diabetes, lesions similar to human diabetic glomerulosclerosis were observed frequently (9 out of 12 cases). It was also noted that adrenal regeneration hypertension caused its development with greater frequency and in a larger extent (6 out of 6) than DCA hypertension (3 out of 6).<BR>(6) No definite symptoms of hypertension were seen in the following four groups of rats : <BR>1. rats with alloxan diabetes only, <BR>2. rats administered with 1% saline solution with or without alloxan diabetes,
- 一般社団法人 日本内分泌学会の論文