下垂体甲状腺系のFeed-back relationに関する研究
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In the present study, the effect of thyroid hormone on the release of I<SUP>131</SUP> from the thyroid gland was investigated to evaluate the "Feed-back relation of pituitary-thyroid axis." The results were summarized as follows.<BR>Experimental studies : <BR>In normal rabbits, the release of thyroidal I<SUP>131</SUP> was promptly and completely inhibited by a single subcutaneous injection of L-thyroxine (T<SUB>4</SUB>) (50μg or 100μg) or 3, 5, 3 triiodo-L-thyronine (T<SUB>3</SUB>) (10μg or 50μg).<BR>However, the same animals showed no marked inhibition following administration of KI in doses equivalent to the iodine contents of T<SUB>4</SUB>.<BR>Following administration of TSH (10-30 Ms.E. every twelve hours for one day), the rate of release of thyroidal I<SUP>131</SUP> was increased to similar level that was seen in normal, even in animals of which the I<SUP>131</SUP> release had been inhibited by T<SUB>4</SUB> injection.<BR>The release of thyroidal I<SUP>131</SUP> in the hypophysectomized rabbit maintained with TSH administration (5 Ms. E. every twelve hours) showed no marked inhibition by T<SUB>4</SUB> injection.<BR>The release of thyroidal I<SUP>131</SUP> in the adrenectomized rabbit maintained with cortisone (0.5-1mg daily) showed marked inhibition by T<SUB>4</SUB> injection, as was observed in normal animal.<BR>From these data, it may be concluded that the inhibitory effect of T<SUB>4</SUB> upon the release of thyroidal I<SUP>131</SUP> was chiefly due to the suppression of endogenous TSH secretion.<BR>Clinical studies : <BR>In normal subjects, a single subcutaneous injection of T<SUB>4</SUB> (1 or 3 mg) caused complete inhibition of the release of thyroidal I<SUP>131</SUP> and increase of PBI level. On the contrary, most patients with hyperthyroidism, even in euthyroid stage, failed to show the inhibitory action of T<SUB>4</SUB> on the release of thyroidal I<SUP>131</SUP><BR>In normal subjects who showed an increase of PBI more than about 2μg/dl twenty-four hours after T<SUB>4</SUB> administration, the percent change of the release rate of thyroidal I<SUP>131</SUP> was found to be snore than about 60%, independent of the amount of increase in PBI. Whereas the percent change of the release rate of thyroidal I<SUP>131</SUP> in hyperthyroid patients who showed a relatively small increase of PBI after T<SUB>4</SUB> administration, was found to be less than those of normal subjects with the same amount of increase in PBI. In hyperthyroid patients who showd a larger increase of PBI, the percent change of the release rate of thyroidal I<SUP>131</SUP> was correlated to the amount of increase in PBI, except a few cases (r=+ 0.50, P<0.02).<BR>From these data, it was demonstrated that the mesurements of the release rate of thyroidal I<SUP>131</SUP> and of PBI after T<SUB>4</SUB> administration were very excellent aids to evaluate the "Feed-back relation" (Feed-back test).<BR>In addition to this test (Feed-back test), other thyroidal function tests were also studied in most cases.<BR>As no correlation was found among the "Feed-back index" (the ratio of percent change of release rate of thyroidal I<SUP>131</SUP> to increase amount of PBI), PBI, BMR, I<SUP>131</SUP>-uptake and exophthalmometry, these items seemed to show different aspects of thyroidal function.<BR>By summarizing these data of the "Feed-back test, " serum TSH level and TSH-test, the author presented a hypothetical schema of the "Feed-back relation of pituitary-thyroid axis" in hyperthyroidism.
- 日本内分泌学会の論文
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