クロールプロマジン及びクロールプロメタジンの血糖に及ぼす影響

概要

論文の詳細を見る
It is widely accepted that chlorpromazine (CP) exert its blocking effect on autonomic nervous system not only peripherally but also centrally. It has previously been reported by us that chlorpromazine suppressed the insulin initial hyperglycemia, and also posessed a hypoglycemic action. The present report deals with the effect of CP and chlorprometazine (CPM) on blood sugar in rabbits. (1) CP has a mild hypoglycemic effect, whereas CPM posessed hyperglycemic action. (2) CP suppressed the insulin initial hyperglycemia while CPM accentuated it. (3) CP augmented the hypoglycemic action of insulin, whereas CPM suppressed it. (4) CP slightly suppressed the hyperglycemic effect of adrenaline. (5) When CP was administered with CPM simultaneously, a marked hyperglycemia was produced. However, this action was inhibited by pre-treatment of dihydroergotamine.