甲状腺刺戟ホルモン (TSH) に関する臨床的並びに実験的研究
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An assay for exophthalmogenic factor in sera of exophthalmic euthyroid and hyperthyroid patients and some hormone preparations was performed by the method based on measurement of the percent increase in intercorneal distance of gold fish following the intracoelomical administration of the test material.<BR>Out of nine normal adults examined, the sera of seven showed a trace of exophthalmogenic response, but the sera of two males exhibited abnormally high response.<BR>In nine exophthalmic hyperthyroidism, three non-exophthalmic hyperthyroidism and one moderately severe exophthalmic euthyroidism and one non-exphthalmic simple goiter a correlation was observed between each couple of exophthalmos grade, serum exophthalmogenic response, serum TSH level and protein bound iodine (PBI) level : the exophthulmos grade correlated significantly with the serum exophthalmic response, but not with the serum TSH level or PBI level.<BR>As regards exophthalmos, gold fish responded well to the administration of thyrotrophic preparation and beef anterior pituitary extract, but scarcely to gonadotrophin, adrenocorticotrophin, cortisone, testosterone, estradiol and thyroxine. Enhancing effect of ACTH on exophthalmos produced by TSH was not marked.<BR>It was postulated that exophthalmogenic factor, originating from anterior pituitary, existed in human sera, and increased in some patients with exophthalmos, but was not TSH. itself.<BR>The serum TSH concentration in rabbits under various experimental conditions was investigated by the in vitro method based on inorganic I<SUP>131</SUP> release of beef thyroid tissue. The following results were obtained.<BR>1) The mean serum TSH level in 20 normal rabbits was 1.9±1.1 milli JS u/ml, and the level of TSH in serum circulating in the internal jugular vein was higher than that in serum obtained from peripheral systemic vein.<BR>2) The serum TSH level decreased markedly 24 hours after hypophysectomy.<BR>3) Ninety-six hours after thyroidectomy the content of TSH in the serum increased to more than 10 milli JS u/ml.<BR>4) Within 12 hours after the administration of 1-thyroxine (T<SUB>4</SUB>) or 1-3 : 5 : 3'-triiodothyronine (T<SUB>3</SUB>), the serum TSH activities fell below the lower limit available for the assay method. The inhibition of TSH secretion by T<SUB>4</SUB> appeared rather gradually but lasted longer than that of T<SUB>3</SUB>. However, it was observed in either occasion that the serum TSH activity was elevated transiently and then returned to the initial level again ; this change was regarded as a "rebound phenomenon".<BR>5) The TSH level in rabbit sera increased with some variations following the medication of mer-cazole (1-methyl-2-mercaptoimidazole), and decreased gradually to the initial level in 1-2 weeks after the cessation of the administration of mercazole.<BR>6) Exogenous TSH, when administered intravenously, disappeared rapidly from the sera of normal rabbits, but somewhat slowly in the rabbits treated with mercazole or carbon tetrachloride.
- 一般社団法人 日本内分泌学会の論文