抗利尿物質に関する研究(第3報):各種の内科的疾患における血漿抗利尿活性度
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概要
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67 determinations of plasma antidiuretic activity in 57 patients with a variety of clinical disorders were performed in the early morning. The results obtained were as follows.<BR>1. Plasma antidiuretic activity was increased in patients with fluid retention.<BR>2. Plasma antidiuretic activity was also increased in 3 diabetics with blood sugar level over 300mg/dl.<BR>3. The significant correlations were found between plasma antidiuretic activity and either volume or specific gravity of 24 hours urines collected on the day the plasma antidiuretic activity was determined.<BR>4. No relationships of plasma antidiuretic activity to plasma sodium, potassium, calcium and sodium plus potassium plus calcium concentrations, were found. However, plasma sodium, and sodium plus potassium plus calcium concentrations of patients with fluid retention revealed to be a little lower.<BR>5. The significant correlations between plasma antidiuretic activity and both serum protein content of edematous patients and serum colloid osmotic pressure, calculated from Iversen's formula, were found respectively.<BR>As the result of this study, it is suggested that the secretion of antidiuretic hormone in patients with fluid retention is regulated by volume-receptors sensitive to the distribution as well as the magnitude of the effective circulating blood volume.
- 一般社団法人 日本内分泌学会の論文