尿ムコ蛋白と副腎皮質機能
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概要
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Very little has been known with regard to physiological significances of the mucoproteins, and it has not yet been well established as to the relationship between blood and urinary mucoproteins. However, some authors reported that the mucoproteins and its related substances in blood were observed increase in cases of the stressed conditions, and these evidences suggest the adrenocortical function may have influence on the excretion of the mucoproteins in urine. In this paper, it was undertaken to clarify the problems on the urinary mucoproteins and the adrenocortical function, and significant correlation were obtained between mucoproteins and total 17-hydroxycorticoids excreted in urine.<BR>Albeaux-Fernet's method was improved and employed to evaluate the urinary mucoproteins (MP), and total 17-hydroxycorticoids (17-OHCS) in urine was determined by the method of Smith et al.<BR>Following results were obtained :<BR>1) Concentrations of MP and 17-OHCS in urines were well correlated in 150 urinary specimens of 25 male healthy adults and in 30 specimens of 5 patients suffering from minimal pulmonary tuberculosis. Their coefficients of correlation were 0.535 and 0.773 respectively, and statistically significant (p<0.001). Total 24-hour excretions of urinary MP and 17-OHCS were also found in good correlation in 125 specimens of 25 male healthy adults (r =0.495, p<0.001).<BR>Moreover, the diurnal rhythms of urinary MP and 17-OHCS have shown similar good correlations in 7 healthy and 14 pulmonary tuberculous subjects.<BR>2) In contrast to the results obtained previously, the correlations between the concentrations of MP and 17-OHCS were not significant statistically in 8 cases of far advanced patient of pulmonary tuberculosis (47 specimens) and 12 aged subjects (54 specimens). Their coefficients of correlation were 0.283 and 0.07 in each.<BR>As evidenced by diurnal rhythms, no excretory parallerism between MP and 17-OHCS in urine was found in the aged group, while in far advanced tuberculous patients, however, there were exhibited in good correlations in spite of the relatively high values observed in urinary MP.<BR>3) Urinary MP was increased by the administrations of ACTH Gel to 14 healthy male adults, while oral administrations of hydrocortisone (100mg) to 2 healthy male subjects did not induce the significant increments of MP in urine.<BR>4) Urinary MP did not correlated with 17-KS significantly in both concentrations and total 24-hour excretions obtained from 24 male healthy adults (123 specimens), and their coefficients of correlation were 0.179 and 0.165 respectively.<BR>5) Using bicycle ergometer, 6 healthy male subjects were observed the effects induced by muscular exertion. In four of them, it was obtained the results that the adrenocortical activation was evidenced by increased outputs of 17-OHCS, 17-KS in urine and eosinopenia in blood, and enhanced excretion of MP in urine were concomitant occurence in these cases, however, the remaining 2 exhibited neither adrenocortical activation nor increased excretion of MP in urine.<BR>6) These evidences are enough to suggest the important roles of adrenocortical function on the excretions of urinary MP, and some of the factors concerning the excretions of MP in urine are also discussed.
- 一般社団法人 日本内分泌学会の論文