糖尿病と甲状腺機能との相関に関する臨床的並びに実験的観察

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概要

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• 1) This article summarily discusses the experimental results of the effects of the thyroid hormone on carbohydrate metabolism. The present investigation was carried out by the departmental staffs.<BR>2) Serum P.B.I., I<SUP>131</SUP> uptake, basal metabolism and cholesterol contents of 62 diabetic patients admitted to our hospital were determined. Two of the 62 patients had hyperthyroidism, of the two one had devloped hyperthyroidism during the course of diabetes mellitus, which was improved by treatment for hyperthyroidism. Generally speaking, severe diabetic patients, having high fasting blood sugar and severe form of glucose tolerance test, were apt to show hypothyroidism.<BR>3) A new method to determine T.S.H. in vitro was recently desingned by appling what I<SUP>131</SUP> release-inhibiting ratio in calf thyroid slice run paralelled with standard T.S.H. concentration (U.S.P.) (Bakke-Ogura modification for plasma T.S.H. determination). By means of this method the normal plasma T.S.H. level was 0.69±0.51 m J.S.E. per ml.<BR>The patients with moderately advanced and severe diabetes mellitus were apt to show elevated plasma T.S.H., especially in three juvenile diabetic patients.<BR>4) Relatively large number of the patients revealed low serum P.B.I. with elevated T.S.H., as the correlation of these two substances were checked in all the diabetic patients. The investigation is being continued for further clarification.<BR>5) The effects of thryoxine and triiodothyronine on carbohydrate metabolism were investigated in vitro, i.e. these hormones accelerated glucose uptake and glycogen synthesis of rat diaphragm and antagonized insuline effects. However, they are antagonistic in two ways, glycolysis and glycogen synthesis, are accelerated in rat liver slice by the hormones. Thyroxine failed to show any effect on oxygen consumption of brain slice.<BR>6) The thyroid function of the alloxan diabetic rat was investigated subsequently by means of I<SUP>131</SUP> radioautograph and thyroid function index.* The following results were obtained. The thyroid function was apt to be increased in the early stage, but was generally decreased in the later stage of the alloxan diabetes. With insulin treatment for the lowered thyroid function in the later stage, the function was able to be improved.<BR>* Thyroid function index = I<SUP>131</SUP> uptake% /thyroid weight / body weight/x 100

• 日本内分泌学会の論文

著者

• 小倉 一

  神戸医科大学第二内科学教室

• 馬場 茂明

  神戸医科大学第二内科学教室

• 恒川 洋

  神戸医科大学第2内科学教室

• 佐古田 雅弘

  神戸医科大学第二内科学教室

• 前田 浩之

  神戸医科大学第二内科学教室

• 恒川 洋

  神戸医科大学第二内科学教室

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