パロチンの新陳代謝に及ぼす影響:(I) パロチンの諸酵素に及ぼす影響
スポンサーリンク
概要
- 論文の詳細を見る
It is reported that Parotin caused a fall of serum calcium, total protein, non-protein nitrogen and amino-N in normal rabbits, an increase in A: G ratio of them and a decrease in urinary nitrogen in normal rats (Takaoka and Yamaguchi). An accerelation of C<SUP>14</SUP>-glycine incorporation into rat liver protein and turn over rate of P<SUP>32</SUP>-RNA in the rat liver after the administration of Parotin was observed (Ishikawa). On this basis Takaoka has presumed that Parotin may take a part in protein metabolism in animals.<BR>This paper is presenting the results of the investigation designed to make clear the influence of Parotin on metabolism, especially on activities of several enzymes and oxydative phosphorylation in rats.<BR>Following results are obtained:<BR>1) An administration of Parotin produced an increase in the activities of liver cathepsine and glutamic-oxalacetic transaminase of the liver and the heart, whereas it caused a decrease in the activity of liver arginase. A decrease in the activity of serum alkaline phosphatase was noted in rabbits, while no change in liver alkaline phosphatase in rats was recognized after the injection of Parotin.<BR>2) We have previously reported that the administration of Parotin accerelates the oxygen consumption by TCA cycle in the rat liver homogenates. As far oxydative phosphorylation is concerned, P: O ratio in the rat liver homogenates given Parotin in advance is demonstrated to be higher than that observed in control rats.<BR>From the results mentioned above, a probable relation of Parotin with the growth hormone in regards with their enzymic actions was discussed in detail, because both of them play important roles in protein metabolism. Considering the protein accumulating and growth promoting actions of Parotin previously reported, the results of this experiment strongly suggest that Parotin may have a hormonal influence on process of protein metabolism. Furthermore, a possible working mechanism and indications of its clinical application of Parotin were discussed in this paper from the stadpoint of physiological actions of adenosine-triphosphosphate.