尿崩症の臨床的観察 (第2報):病因に関する統計的考察
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概要
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The etiology of 269 cases of diabetes insipidus which have been reported in Japanese literatures since 1927 was analized statistically, and the following results were obtained:<BR>(1) Causative diseases and their frequency: Idiopathic 116 cases (43.1), symptomatic 105 cases (39.0%), familiary 27 cases (10.1%) and others 21 cases (7.8%). Among symptomatic cases neoplasms were 51 cases, being the highest, and Hand-Schüller-Christian's disease 18 cases, syphilis 16 cases, during pregnancy and following delivery 11 cases, trauma 5 cases, tuberculosis 3 cases and encephalitis 1 case.<BR>(2) Among cases with detailed description of the findings at postmortem examination, 6 cases had destructive lesions of both hypothalamus and pituitary gland, being the highest, and 2 cases had lesion limited to hypothalamus and 1 case with lesion limited to the posterior pituitary.<BR>(3) Age of onset: In cases with idiopathic and familiary, the onset was before 10 years old in over 60%, whereas in symptomatic cases an even distribution was noted up to 40 years old.<BR>(4) Sex: Ratio between male and female was 2.01: 1.<BR>(5) As for precipitating factors, the relationship between diabetes insipidus and heredity, pregnancy and trauma was discussed. It was also pointed out that febrile illness and surgical intervention could also act as a triger. Cases with optic atrophy of unknown origin complicated with diabetes insipidus were also discussed.<BR>(6) Diabetes insipidus is a relatively rare disease and there were 18 cases among 18,561 inpatients treated in our clinic during 28 years between 1927 and 1954, namely approximately one every 1,000 admissions.
- 一般社団法人 日本内分泌学会の論文