結核症に於ける生体の変調に関する研究:-特に塩類熱を指標とした脾臟機能の変調に就いて-
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概要
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1) If normal rabbits were injected 5 per cent solution of NaCl in a dose of 1 cc per kg of their bodyweight(a small dose), or 4 cc per kg(a great dose), or 5 per cent solution of CaCl<SUB>2</SUB> in a dose of 1cc per kg of their bodyweight (a small dose), or 4 cc per kg (a great dose), the following responses were manifested ; they did not react to a small dose of Na-stimulus and reacted with a fever to a great one, and also reacted with a fever to a small dose of Ca-stimulus and with a fall of their body temperature to a great one. But, if the rabbits were infected with tuberculosis by the method of pouring tuberculous bacilli into their trachea, they showed the following responses after 22-24 days later, when tuberculin reaction became positive, they did not react to both a small and a great dose of Na-stimulus and to a small dose of Ca-stimulus and then reacted for the first time with a fever to a great dose of the latter.<BR>This abnormal reaction of the salt-fever indicated that the rabbits with tuberculosis became dull to the salt-stimuli.<BR>2) If normal rabbits were injected the serum of the rabbits with tuberculosis in a dose of 3 cc per kg of their bodyweight and examined their responses to the afore-mentioned salt-stimuli 20 minutes later, they showed the abnormal reaction of the salt-fever as the rabbits with tuberculosis.<BR>This fact indicated that active factors, which made positively the responses to the salt-stimuli dull, were generated in the blood of the rabbits with tuberculosis.<BR>3) These active factors were found in a high grade in the splenic venous blood of the rabbits with tuberculosis at the earlier stage, when the tuberculin-reaction had not yet become positive and the action of these factors had not been observed so strongly in the general blood. These disappeared from the blood in the rabbits with tuberculosis by their splenectomy. If the spleen of the rabbits with tuberculosis was transplanted to a normal rabbit, the afore-mentioned abnormal reaction of the salt-fever became to occur in the latter, but the rabbits with tuberculosis that were transplanted with a spleen of normal rabbits showed again a former and normal reaction of the salt-fever.<BR>It was indicated by these experiments that these active factors were products of the aberrated splenic function as a result of infection with tuberculosis.
- 日本内分泌学会の論文