Cd38 gene knockout juvenile mice: A model of oxytocin signal defects in autism

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概要

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• Oxytocin (OXT) in the hypothalamus is the biological basis of social recognition, trust, and bonding. We showed that CD38, a leukaemia cell marker, plays an important role in the hypothalamus in the process of OXT release in adult mice. Disruption of Cd38 (Cd38-/-) produced impairment of maternal behavior and male social recognition in mice, similar to the behavior observed in Oxt and OXT receptor (Oxtr) gene knockout (Oxt-/- and Oxtr-/-, respectively) mice. Locomotor activity induced by separation from the dam was higher and the number of ultrasonic vocalization (USV) calls was lower in Cd38-/- than Cd38+/+ pups. These phenotypes seemed to be caused by the high plasma OXT levels during development from neonates to 3-week-old juvenile mice. ADP-ribosyl cyclase activity was markedly lower in the knockout mice from birth, suggesting that weaning for mice is a critical time window of differentiating plasma OXT. Contribution by breastfeeding was an important exogenous source for regulating plasma OXT before weaning by the presence of OXT in milk and the dam's mammary glands. The dissimilarity of Cd38-/- infant behaviour to Oxt-/- or Oxtr-/- mice can be explained partly by this exogenous source of OXT. These results suggest that secretion of OXT into the brain in a CD38-dependent manner may play an important role in the development of social behavior, and mice with OXT signalling deficiency, including Cd38-/-, Oxt -/- and Oxtr-/- mice are good animal models for developmental disorders, such as autism. © 2011 Pharmaceutical Society of Japan.

• Pharmaceutical Society of Japan = 日本薬学会の論文

著者

• Higashida Haruhiro

  Department Of Biophysical Genetics Kanazawa University Graduate School Of Medical Science

• Minabe Yoshio

  Department Of Psychiatry And Neurobiology Kanazawa University Graduate School Of Medical Science

• Kikuchi Mitsuru

  Department Of Clinical Laboratory Toride Kyodo General Hospital

• Munesue Toshio

  Osaka University United Graduate School Of Child Development:kanazawa University United Graduate Sch

• Yokoyama Shigeru

  Department Of Applied Science For Electronics And Materials Kyushu University

• Munesue Toshio

  Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University

• Lopatina Olga

  Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University

• Minabe Yoshio

  Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University

• Kikuchi Mitsuru

  Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University

• Higashida Haruhiro

  Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University

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