Polyphenols from Sophora yunnanensis, and Their Inhibitory Effects on Nitric Oxide Production
スポンサーリンク
概要
- 論文の詳細を見る
A new flavonoid, (2R,3R)-3,7,4′-trihydroxy-3′,5′-dimethoxyflavanone, named sophorayunnanol (1), together with eight known polyphenols (2—9), were isolated from the roots of Sophora yunnanensis C.Y.MA (Leguminosae). The structure including absolute stereochemistry of 1 was determined by spectroscopic (high resolution (HR)-MS, 1D- and 2D-NMR, and circular dichroism (CD)) methods. The inhibitory activity of these compounds was examined against nitric oxide (NO) production by lipopolysaccharide (LPS) and interferon (IFN)-γ activated macrophages, RAW264.7 cells. 3,7,3′,5′-Tetrahydroxy-4′-methoxyflavone (6) and piceatannol (9) showed potent inhibitory activity against the production of NO with IC50 values of 14.4±2.5 and 12.9±1.8 μM, respectively. This article is the first report on phytochemical study of S. yunnanensis.
- 公益社団法人 日本薬学会の論文
公益社団法人 日本薬学会 | 論文
- Effects of Nutrition Support Team Services on Outcomes in ICU Patients
- The Mechanisms of Insulin Secretion and Calcium Signaling in Pancreatic β-Cells Exposed to Fluoroquinolones
- Intrathecal Ketamine and Pregabalin at Sub-effective Doses Synergistically Reduces Neuropathic Pain without Motor Dysfunction in Mice
- Discovering Some Novel 7-Chloroquinolines Carrying a Biologically Active Benzenesulfonamide Moiety as a New Class of Anticancer Agents
- Novel Insights into Disease Modeling Using Induced Pluripotent Stem Cells