針麻酔の鎮痛の発現にあづかるド-パミン系

概要

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The involvement of the dopaminergic system in acupuncture and morphine analgesia, measured by tail-flick test in rats has been investigated by observing the changes in acupuncture analgesia after treatment of a dopaminergic blocker, pimozide.<BR>Acupuncture analgesia was completely antagonized by pimozide (4 mg/kg), while pimozide had no influence on the threshold of pain. Antagonistic action of pimozide on acupuncture analgesia was dose dependence.<BR>Morphine analgesia was also completely antagonized by pimozide, and pimozide antagonized stimulation-produced analgesia caused by stimulation of acupuncture afferent pathways such as the dorsal periaqueductal central gray (PAG), the lateral septum and the anterior hypothalamus.<BR>Pimozide did not antagonize the analgesia produced by stimulation of the ventral PAG which is one of the origins of acupuncture efferent pathways.<BR>These data indicate that the dopaminergic system is involved in acupuncture afferent pathways.
学校法人昭和大学・昭和医学会の論文