エンドトキシンショックにおける肺機能の変化

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概要

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• Pulmonary function and hemodynamics in experimental endotoxin shock were studied in dogs. They were anesthetized by intravenous administration of pentobarbital and ventilated mechanically. Shock was caused by intravenous administration of E. Coli endotoxin (3 mg/kg LD<SUB>100</SUB>) . Dogs were divided in three groups as follows.<BR>Group 1 (G-1) ; administration of Et, alone, Group 2 (G-2) ; posttreatment with aspirin (75mg/kg) after administration of Et. as in Group 1, Group 3 (G-3) ; posttreatment with low molecular weight dextran solution (20ml/kg) after adminstration of Et. as in Group 1.<BR>1) A-aDo<SUB>2</SUB> increased in the same degree in both G-1 and G-2, but it increased in the latter more than in the former 120 minutes after administration of Et. On the contrary, in G-3 it decreased markedly 60 minutes after the administration of Et.<BR>2) The pattern of increase in a-ADn<SUB>2</SUB> was similar in G-2 and G-1. However in G-3, a-ADn<SUB>2</SUB> decreased following infusion and this tendenccy unchanged throughout the experiment.<BR>3) Closing volume increased gradually in G-1. In G-3 the increase was very slight for 120 minutes, but it increased significantly 180 minutes after administration of Et. and its increase was most marked among three groups.<BR>4) FRC showed little change in both G-1 and G-2. On the other hand, it increased gradually in G-3, though its increase was very slight.<BR>5) Pao2 fell gradually and slightly in G-2 compared with G-1, but in G-3 it increased slightly as compared with control value throughout the study.<BR>6) G-2 showed the best results among three groups in the degree of recovery in mean arterial pressure, base beficit and pHa. On the other hand, G-3 was best in the recovery of central venous pressure for 180 minutes and the cardiac output for 60 minutes after the administration of Et.<BR>In conclusion, both the intravenous administration of aspirin and low molecular weight dextran solution were similarly effective in circulatory changes caused by Et., while the latter was superior to the former as for the alternation of the pulmonary functions.

• 学校法人 昭和大学・昭和医学会の論文

著者

• 武田 昭平

  昭和大学医学部麻酔学教室

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