針鎮痛有効性の個体差とモルヒネ鎮痛及び中脳中心灰白質刺激による鎮痛の個体差の相関

概要

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Rats were classified into either acupuncture effective animals or noneffective animals by a significant increase (p<0.05) in tail-flick latency which was estimated as pain thresholds.<BR>Morphine analgesia which was induced by intraperitoneally injected 0.5 mg/kg of morphine was also observed in acupuncture effective animals, while such doses of morphine were not effective to couse analgesia in acupuncture non-effective animals.<BR>Analgesia caused by periaqueduct central gray stimulation was also observed in acupuncture effective animals, while it was not observed in acupuncture non-effective animals.<BR>These data did not deny the previous our observations that the individual variation in effectiveness of acupuncture analgesia is primary due to the individual variation in content of endogenous morphine like factors, however it was supposed that the individaual variation of other factors such as other neurotransmitters may involve in individual variation in effectiveness of acupuncture analgesia.