術前患者の不安並びにそれに伴なう睡眠障害に対するMinor tranquilizerの薬効について--Double blind methodによるMS-4101(Flutazolam)の臨床評価

概要

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Using the double blind method, new tranquilizer MS-4101 (Ro 7-6102) and placebo were compared in surgical patients. Either 10mg of MS-4101 or placebo was given orally, once daily, to patients for 3, 5 or 7 days before the day scheduled for surgical procedures. A simple scoring system based on the observation of the patient's behavior and answers to standardized questions has been used. Results were statistically analyzed. Anxiety grade of patients were classified according to Manifest Anxiety Scale (MAS) . Judging from the global evaluation of the effects based on the score of "anxiety", "getting to sleep" and "state of sleeping", MS-4101 was effective in the high anxiety group, particularly in the 7 days-therapy group.
昭和大学・昭和医学会の論文