Monoamine Oxidaseに関する研究-38-種々ラツトの臓器内MAO活性に対するNitriteおよびNitrate化合物の影響〔英文〕

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The effects of nitrites and nitrates on MAO activities from liver, brain, kidney and heart were studied with tyramine and benzylamine as substrate. MAO activity was determined manometrically.<BR>With tyramine as substrate, the MAO activities of brain, kidney and heart increased with increase in the concentrations of sodium nitrite and potassium nitrite, but the activity of liver did not change. Amylnitrite inhibited the activities of liver, brain and kidney strongly and that of heart slightly.<BR>With benzylamine as substrate, the MAO activities of liver and heart increased markedly, that of brain increased slightly and that of kidney decreased with increase in the concentration of sodium nitrite.<BR>With benzylamine as substrate the activities from the four organs increased on addition of potassium nitrite. The activities of liver, brain and kidney decreased gradually with increase in the concentration of amylnitrite, but that of heat increased.<BR>Thus the MAO activities from brain, kidney and heart were increased by all the nitrites tested, except amylnitrite, and were inhibited by nitrates.
学校法人昭和大学・昭和医学会の論文