慢性閉塞性動脈疾患に関する研究--特に133Xenon clearanceを中心として

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The author attempted to grasp the hemodynamic phase of lower extremities in sixtyone patients with chronic obstructive arterial disease (TAO forty-eight, ASO thirteen) including twenty-nine control subjects without ischemic symptom, by means of directly intramuscular injection of 133 Xenon (30-100 μci) and recorded it's clearance curve. The following six parameties were measured from the clearance curved and the results. were discussed with clinical symptoms, plethysmograms and arteriograms. (1) Rest Muscle Blood Flow (MBFR) (2) Muscle Blood Flow during exerese (MBFE) (3) Postexerise Muscle Blood Flow (MBFH) (4) Duration time from the cessation of exercise to postexercise hyperemia (T-time) (5) Index indicating hyperemia one minute after the cessation of exercise (R-indx) (6) The angle between the horizontal line and the tangent line which was drawn at the clearance curve one and half minute after the beginning of exercise curve was stabilized (γ Angle) . The author also evaluated the clinical utility of RI-Scintigram and acid-base balance in occulusive arterial disease. The peripheral micro circulation insufficiency is thought to be result in metabolic acidosis and in PH decrease in peripheral capillary blood. PH measurement is also instrumental in the study of morbidity of ischemic extrimity of the chronic obstructive arterial disease.