実験癌における免疫学的研究
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概要
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At present, articles on immunity to cancer have become the topic of interest among many physicians. The auther studied the existence of immunity to experimental cancer (Ehrlich's ascites tumor of mice), immunospecifity of tumor cells, and the effects of the combined therapy of immunological procedures and cytotoxic antibiotics.<BR>Results were as follows:<BR>1) Some effect on the prolongation of survival time, were observed even by using of some kinds of protein such as ovialabumin.<BR>2) The survival times in mice were prolonged, when the cancer cells were inoculated after immunization of inactivated cancer cells. In the same manner, an effect on the prolongation of life survival were observed up to a point by passive immunization.<BR>3) The effect of immunization on the prolongation of life in these cases were greater than that of the immunization by liver homoginate of the mouse.<BR>4) A little diff erenc in the effects between the combined therapy of immunization and the single treatment of of each agents was noted.<BR>5) When the gell-diffusion method was applied, a precipitation line was observed between the Ehrlich ascites cancer cell extract, and the antiserum againt of the Ehrlich ascites tumor or its euglsbulin fraction or 7 s-r-globulin fraction. There was also a precipitation line between the antimouce-liver rabbit serum (or its euglobutin fraction) and liver homoginate.: However, no cross-reaction was observed between the cancer cell and the liver cell.<BR>6) In view of the above mentioned, the cancer cell is considered to have an immunological specificity to some extent against the normal cell.<BR>7) A cytolytic phenomen of the Ehrlich ascitis cancer cell was seen not only by the Ehrlich ascites anti-serum and its euglobulin fraction but also to some extent by its pseudoglobulin and albumin fraction. Complements for reaction were necessary in all of these reactions.
- 学校法人 昭和大学・昭和医学会の論文