白血球および白血病細胞のペルオキシダーゼに関する研究

概要

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The peroxidase reaction on blood smears of leukemic patients was investigated and the peroxidase isolated from Shay's chloroma was compared with those in normal cells. The results obtained were as follows: 1) The peroxidase positive and negative myeloblasts reacted in the same way to the antileukemic agents in acute leukemia, showing a specific pattern of behavior in each case. 2) In chronic leukemia, the peroxidase negative meloblasts were discovered in peripheral blood during acute exacervation. 3) The peroxidase activity measured with cell suspension was low in leukemia. The influence of PH on peroxidase activity was different between leukemic and normal cells. 4) Peroxidase was found in the highest concentration in mitochondria in subcellullar fractions. 5) Peroxidase bound with protoporphyrin in chloroma was compared chemically with normal myeloperoxidase. 6) The detoxification which was proved experimentally as the biological activity of peroxidase was influenced by halogen ions. 7) The mode of existence of peroxdase in the cell might be one of the factors controlling positive or negative peroxidase reaction on myeloblasts.
学校法人昭和大学・昭和医学会の論文