中毒性貧血を主とした肝の低酸素症病変について
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The present histopathologic studies were performed by the following ways. Parathion was subcutaneously injected into mice devided into groups receiving 2 mg/kg, 4 mg/kg, 8 mg/kg, 16 mg/kg and 24 mg/kg, respectively, twice a week. Secondary, on completion of the above mentioned injections, (for a total 12 times), the female mice were mated with male mice. The newborn young from them were killed on the 3rd day of life, and were subjected to histopathathologic examinations as were the livers withdrawn from the mothers (about 8 months after birth) . Hematological examinations comprising erythrocytes, hemcglohin, erythrocyte resistance, erythrocyte diameter, etc. were also done.<BR>1. The animals given 24 mg/kg (to 4 times injected) to 16 mg/kg (to 8 times) as acute groups exhibited the following histopathologic findings of the liver : the irregular funicular arrangement, cloudy swelling, and vacuolar degeneration of the liver cells; nuclear degeneration; loss of glycogen; capillary hyperemia; and the congestion of the central vein.<BR>2. The animals given 8mg/kg, 4mg/kg (9-29 times) or 2 mg/kg (25-61 times) as the subacute and chronic groups showed the histopathologic changes of cytologic degeneration of the liver more marked with the lapse of time than in the acute groups. At the same time edema was observed around the central vein, in the stroma, and around the blood vessels. In the subacute group, the hypertrophy and edematous dilatation of the interlobular connective tissue were especially remarkable, which seemed to tend progress into fibrosis as tissue reaction and reparatory process. Changes due to histologic damages (lytic changes and necrotic area) were of the highest incidence in the group given 4 mg/kg.<BR>3. The histologic findings in the newborn young consisted mainly of the pathologic changes of parenchymal cells, the congestion of the central vein, and the edema of Glisson's capsules.<BR>4. The pathologic changes in the young were generally similar to but milder than those in the mothers. Those less pathologic changes in the young may have come from the inhibition, by the placental barrier, of the transfer of metabolic disturbance from mother to fetus.<BR>5. As for the hematologic findings, the erythrocytes and hemoglobin showed an anemic tendency increasing with time. Very slight unevenness in the size of erythrocytes and the deformation of erythrocytes wers observed. The minimal erythrocyte resistance was practically normal, while the maximal erythrocyte resistance tended to drop, mostly in the 8 mg/kg group and the 4mg/kg group.<BR>6. In the acute and chronic deaths following the admininistration of Parathion, the hepatic histologic changes including cytologic changes and stromal changes were found practically paralleled to the hematologic changes observed.<BR>7. The mechanism of develpment of various hepatic pathologies as observed in the present experiment is believed to be as follows. Parathion administered causes directly the changes of the parenchymal cells and brings about toxic anemia due to the abberation and change of the blocd elements, resulting in hypoxidose. The hypoxia affects the blood-vessel walls, damages the liver cells and produces reticular fibrosis due to the edema and edematous changes in the stroma and around the blood vessels. Those changes are followed by the develpment of reparatory process. At the same time, the above changes have the possibility of developing into edemasclerosis, which may strongly tend towards fibrotic sclerosis
- 学校法人 昭和大学・昭和医学会の論文