慢性気管支炎に関する細菌学的,免疫学的研究
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概要
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Bacteriologic and immunologic studies were made on the patients with chronic respiratory diseases. Patients were divided into three groups: bronchial asthma (group I), chronic bronchitis (group II), and other diseases which consist of bronchiectasis, pulmonary emphysema and pulmonary fibrosis.<BR>1. There was no sex difference among the three groups. Most patients of group I distributed on the ages from the third to the fourth decade; but in group II and III the number of patients increased as the age advanced.<BR>2. Streptococcus viridans and Neisseria were respectively found in 96 percent of the patients studied. Hemophilus group considered as an etiologic agent in chronic bronchitis were found in 56 percent of the patients under the study, while Staphylococcus aureus, Diplococcus pneumoniae, and Streptococcus hemolyticus were found in 16, 13 and 39 percent respectively. There was no significant difference among the three groups, except that the percentage of positive cultures of gram-negative bacilli in the sputum of the patients of group III was higher than the other two groups.<BR>3. In the sensitivity tests to antibiotics of pathogenic organisms isolated from the sputum, there was nothing specially to mention except for the more frequent detection of penicillin resistant Staphylococci in group III.<BR>4. About two-thirds of 37 strains isolated as Hemophilus group were identified as Hemop hilus influenzae by the requirement of V-facter and X-factor for growth, and by the agglutination test with specific antiserum. Thus it was thought that Hemophilus influenzae might be found in about 36 percent of the patients with chronic respiratory diseases.<BR>5. By means of transtracheal aspiration, the incidence of positive cultures of pathogenic organisms in the patients which were considered to have bronchial infection was much lower than the expectation.<BR>6. There was no remarkable difference among the three groups as to ASLO titer, and most of ASLO titers were below 166 units which was considered to be normal limit.<BR>7. There was no remarkable difference among the three groups as to ASTa (antistaphy-lolysin) titer, although group II showed a slightly high value than the other two groups.<BR>8. As to the titers of antibodies to Hemophilus influenzae, group II and group III showed higher value than group I. Most patients, in whom positive cultures of Hemophilus group were obtained in their sputum or throat, showed high antibody values. In view of this fact, it was thought that Hemophilus influenzae has much to do with the chronic infection of the respiratory tract.
- 学校法人 昭和大学・昭和医学会の論文