男子不妊症の治療に関する研究
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概要
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1. Diencephalon is known to possess the sexual center of high level. It is indispensable, therefore, to attempt fundamental central treatment of the diencephalon for the improvement of the sexual functions aside from the administration of Gonadotropin or Androgen.<BR>As the treatment of male sterility, the author attempted the irradiation of X-ray on the diencephalon as well as the treatment by so-called rebound phenomenon due to the administration of an excessively large amount of Androgen. Besides, in an attempt to know the mode of action assays were made on varying kinds of hormons.<BR>2. A single time irradiation of X-ray 200 roentgen on the diencephalon of normal males was found to cause a considerable variation in the number of circulating eosinophiles and in the content of blood sugar demonstrating that X-ray irradiation has a fairly strong influence on the diencephalon.<BR>Moreover, out of the 21 cases of male sterility received X-ray irradiation of 100 roentgen twice per week for 3 weeks, increase in the sperm count was recognized on 13 cases. Excretion of 17-KS and fructose in the urine was found to have increased after irradiation, but that of Gonadotropin in the urine showed no appreciable difference.<BR>3. On determination of Gonadotropin and 17-KS, the development of rebound phenomenon was observed on a castraied male patient administered of Testosterone heptanoate in a weekly dose of 200 mg successively for 8 weeks. Likewise, the occurrence of rebound phenomenon was observed on 2 cases of male sterility administered of Testosterone heptanoate in a dose of 250 mg twice per month for 2 months. In the patient of spermia, the appearance of sperm was negative, but there was a marked increase in the number of sperm in the patient of oligospermia.<BR>Occurrence of rebound phenomenon was also confirmed on 2 normal males and 3 cases of oligospermia administered of an excessive amount of Testosterone preparation over a prolonged period of time.
- 昭和大学・昭和医学会の論文
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