Caeruloplasminの家兎末梢血液および骨髓に及ぼす影響について

概要

論文の詳細を見る
Caeruloplasmin was purely isolated from blue globulin substance which was isolated from 10 folds redistilled water diluted pig plasma by acetic acid precipitation at pH 5.9. The purity of this substance was checked by supercentrifugation at 59910 r. p. m. in order to get symmetrical and narrow peak without any splits. After repeated injection of oxidized and reduced caeruloplasmin to rabbits intramuscularly, peripheral blood pictures and bone marrow were investigated. The results obtained were as follows. I) In the cases of reduced form (Cu+-glycoprotein), the number of erythrocytes were increased accompanying with relative lymphocytosis. The young cells of erythropoietic systems were increased with shift to the left. It seems that caeruloplasmin operates by increasing the rate of erythrocytes production and maturation as well as the rate of release of the erythrocytes from the blood-forming tissues. II) In cases of oxidized form (Cu++-glycoprotein), the cells of granulopoietic systems were increased. Bone marrow showed generally hyperplastic pictures. ATP had an effect on the rate of erythropoiesis in these cases. III) Injection of ATP to rabbits induced no change in bone marrow. In short, caeruloplasmin promotes increased cellular division of already existent erythropoietic precursors as well as augmenting division of stem cells into erythrocyte production.
昭和大学・昭和医学会の論文