他動運動訓練による末梢神経再生促進効果に関する基礎的研究--axonotmesisとneurotmesisによる違い

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This study examined whether passive range-of-motion exercise training enhances regeneration of severe peripheral nerve damage in rats. A sciatic nerve damage model was prepared either by axonotmesis or neurotmesis. Twenty-five rats were used and evenly divided into five groups, that were subjected to (1) neurotmesis followed by epineural suture and passive exercise training, (2) neurotmesis followed by epineural suture without training, (3) axonotmesis followed by passive exercise training, (4) axonotmesis followed by no training, and (5) no injury and no training used as controls. Passive exercise training was initiated on the day after injury. After a 4-week period of passive exercise training, nerve regeneration was evaluated by singlefiber electromyography (SFEMG) . In the axonotmesis group, the amplitude, latency, and duration time were significantly improved in the passive exercise training group compared to those in the control group. In the neurotmesis group, the amplitude alone was significantly improved in the passive exercise training group compared to those in the control group. It was concluded that passive exercise training enhances regeneration of peripheral nerve damage.
学校法人昭和大学・昭和医学会の論文