耳鼻咽喉科感染症に対するAM-715の臨床的検討

概要

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The efficacy of AM-715 on infectious diseases of Otorhinolaryngologic field was evaluated. The results obtained were as follows.1) AM-715 was used for 15 patients with infectious diseases of ear, nose and throat. As to the overall clinical efficacy of this drug, the ratio of effectiveness was 60%.2) With respect to the bacteriological results, AM-715 was confirmed to have superior efficacy against infectious diseases due to Staphylococcus aureus, pseudomonas aeruginosa, E. coli and Krebsiella as compared to that of pipemidic acid and nalidixic acid.3) It was found that a mean value of concentration of this drug in the human faucial tonsils was 0.84ug/g at 2 hours later following an oral administration in dose of 200mg.4) There was no side effect due to this drug.From these results, AM-715 was considered to be one of the excellent chemotherapeutic drugs for the infectious diseases of ear, nose and throat.
耳鼻咽喉科臨床学会の論文