Pollinosis and autonomic nervous system. Its influence on the effects of antiallergic agents.:-Its Influence on the Effects of Antiallergic Agents-

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An investigation was carried out to identify autonomic nervous system factors which may be directly involved in the induction of attacks of pollinosis and to determine how an antiallergic agent is affected by changes in the autonomic nervous system.Autonomic nervous system function was evaluated from the R-R interval trendogram pattern on the supine resting ECG and its changes in response to stimulation (i. e., rising and Aschner's ocular compression).(1) The central autonomic nervous tension shifted to the parasympathetic side and the peripheral parasympathetic response was diminished only upon stimulation through baroreceptors; (2) the administration of the antiallergic agent Azeptin® (azelastine hydrochloride) which was started one week before the flowering of cedar trees completely inhibited attacks of pollinosis in 12 of 15 patients (80.0%) with a negative response to Schellong's test, but in none of 10 patients with a positive response. This findings suggested that pathological conditions in the autonomic nervous system which induce a positive response to Schellong's test are directly related to the occurrence of allergic reactions.In a second study the next year (when cedar pollen was more densely distributed), Azeptine alone was administered to patients with a negative response to Schellong's test, and it was combined with Methylcobalamine for patients who tested positive. Attacks were completely inhibited in 30 of 33 patients (90.9%). In summary, the effect of antiallergic agents can be enhanced to a remarkable extent by the concomitant medical treatment of disorders of the autonomic nervous system.

Pollinosis and autonomic nervous system. Its influence on the effects of antiallergic agents.:-Its Influence on the Effects of Antiallergic Agents-

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