原発巣不明の頸部 Malignant Oncocytoma の一例

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A 67-year-old housewife complained of a painless cervical tumor of ten years duration which had grown rapidly during the past two months. On physical examination, there was a well demarcated, movable, elastic hard tumor in the right middle cervical region. Although it was suspected to be metastatic, no primary lesion or abnormality was found in the head or neck. The tumor was easily removed under local anesthesia, although it adhered to the internal jugular vein. The excised specimen was 43×22×21mm in size and 16.6g in weight with an irregular surface. Histological examination showed large atypical cells with abundant eosinophilic granular cytoplasm, which partly formed an acinar structure. Transmission electric microscopy (TEM) revealed a large number of mitochondria of various shapes and sizes in the tumor cell. These pathological findings are those of malignant oncocytoma. The patient died of brain metastasis two years later.
耳鼻咽喉科臨床学会の論文