点滴静注と筋注によるアミノ配糖体耳毒性の比較--ゲンタマイシンを中心に(福井医科大学耳鼻咽喉科学教室開講記念論文)

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Comparative ototoxicity and nephrotoxicity studies of gentamicin between 60-minute intravenous infusion and intramuscular administration were carried out using a total of 36 rabbits. The following results were obtained:At the dose of 30mg/kg, there was no difference in ototoxicity and nephrotoxicity between 60-minute intravenous infusion and intramuscular administration.At the dose of 40mg/kg, almost similar ototoxicity was observed via both administration routes. However, deaths that are considered attributable to nephrotoxicity were found in more animals in the 60-minute intravenous infusion group than in the intramuscular administration group. This result indicates that the risk of ototoxicity may be secondarily increased by a retarded excretion of gentamicin.The dose of 40mg/kg was considered to be the threshold to develop significant nephrotoxicity and ototoxicity by 60-minute intravenous infusion.
耳鼻咽喉科臨床学会の論文