Chronic myelomonocytic leukemia with first manifestation of the submandibular swelling; A report of case.
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概要
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Chronic myelomonocytic leukemia has been classified into myelodysplastic syndromes according to FAB co-operative group proposal. A 76-year-old man was diagnosed chronic myelomonocytic leukemia according to the FAB criteria. Clinical features of the patient were swelling at submandibular region and anemia, but not accompanied by spleno-hepatomegaly, swelling of the systemic lymphnodes and bleeding tendency. In hematological findings, white blood cells and monocytes increased, and myeloid precursors infiltrated the peripheral blood. Bone marrow biopsy specimens showed hypercellularity of myeloblasts and monoblast. In laboratory data, serum and urine lysozyme levels were remarkably elevated. Philadelphia chromosome was negative.<BR>The patient was treated with a small dose of VP-16 against thrombocytopenia, which was thus controled. An immunohistochemical staining of bone marrow cells was performed. Lvsozyme was strongly positive for leukemic myelomonocytic cells. arAntichymotripsin was only positive for monocyts.
- 社団法人 日本口腔外科学会の論文