PHARMACOLOGICAL ACTIONS OF O-BENZOYLTHIAMINE DISULFIDE

スポンサーリンク

概要

• 論文の詳細を見る

• General pharmacological properties and toxicity of O-benzoylthiamine disulfide (BTDS) were studied and the following findings were obtained.1. General Pharmacological ActionIn the respiratory and circuratory systems BTDS behaved qualitatively similarly to thiamine hydrochloride, but quantitatively the former showed a little stronger activity. A dose of 5mg/kg BTDS resulted in the gradual fall of the blood pressure of the rabbit, somewhat more marked than 5mg/kg thiamine hydrochloride. However, no effect was detected on the respiration of the animal. Upon the isolated toad heart, 10-6 M BTDS showed a slight inhibitory action and at concentrations higher than 10-4 M the derivative inhibited more markedly the amplitude of the hart beat. In the case of thiamine hydrochloride, similar effect was seen at 10-5 M, and it was more marked at higher concentrations.Upon smooth muscle organs, the mode of action of BTDS was quantitatively the same as thiamine hydrochloride. BTDS showed scarcely any vasoconstrictive effect on the rabbit auricular vessels similarily to thiamine hydrochloride. On the motility of the isolated rabbit intestine BTDS revealed inhibitory action, lowering the tonus at concentrations higher than 10-4 M, whereas thiamine hydrochloride did not show any effect at the concentration of 10-3 M. In the rabbit uterus in situ, normal movement was observed without any effect of 5mg/kg BTDS or thiamine hydrochloride given intravenously.On the contrary, Tsunoo (3) had reported that the rabbit respiration was somewhat accerelated, the blood pressure rose a little, auricular vessel was dilated and the tonus of the isolated rabbit uterus was increased following an intravenous administration of BTDS. The contradiction between the findings of Tsunoo and of the author is possibly due to the difference in the dose of BTDS. Both have the same view that BTDS has a little stronger pharmacological action than thiamine hydrochloride.2. ToxicityThe LD50 values of BTDS for mice were found to be definitely high in intravenous, intraperitoneal and oral administrations in comparison with thiamine hydrochloride.Following the oral administration of a large dose of BTDS to rats for 6 months, a significant growth promotion was observed without marked changes in blood cell counts, hemoglobin contents and leucocyte distributions, and neither change nor damage was observed pathologically.

• 日本ビタミン学会の論文

著者

• KOBAYASHI H.

  Osaka University

• KOWA Yoshio

  Osaka Research Division, Biological Research Laboratories, Tanabe Seiyaku Co., Ltd.

• YASUDA KOZO

  Osaka Research Laboratory, Tanabe Seiyaku Co. Ltd.

関連論文

• IMP-09: Dynamic and Quasi-Static Tensile Properties of Welded Butt Joint Subjected to Pre-Fatigue(IMP-II: IMPACT BEHAVIOR OF MATERIALS AND STRUCTURES)
• IMP-07: Prediction of Mechanical Behaviour of Low Carbon Steel at High Strain-Rate Using Thermal Activation Theory and Static Data(IMP-I: IMPACT BEHAVIOR OF MATERIALS AND STRUCTURESG)
• PHARMACOLOGY OF A NEW HYPNOTIC DRUG: HQ-355
• PHARMACOLOGICAL ACTIONS OF O-BENZOYLTHIAMINE DISULFIDE
• STUDIES ON THIAMINE DISULFIDE:II. BIOLOGICAL PROPERTIES OF O-BENZOYLTHIAMINE DISULFIDE

スポンサーリンク