Inhibition of Cobamide Coenzyme Activity by a Polypeptide Derived from the Cell Wall of Lactobacillus leichmannii

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概要

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• The cell wall and ribosomes of Lactobacillus leichmannii ATCC 7830, a vitamin B12-requiring organism, have been shown to inhibit the cobamide coenzyme-dependent propanediol hydro-lyase (EC 4.2.1.28) reaction. A B12-binder (polypeptide) of the wall was isolated and purified as a B12-polypeptide complex (4). The complex, when treated with an alkaline solution, resulted in detachment of B12 from the polypeptide. The free polypeptide, upon neutralization, could bind B12 again and cobamide coenzyme as well, thus capable of inhibiting the enzyme reaction. Comparison was also made of this polypeptide with a hog intrinsic factor preparation in the inhibition.

• 日本ビタミン学会の論文

著者

• 佐々木 孝

  Fermentation Research Laboratories, Sankyo Co., Ltd.

関連論文

• Inhibition of Cobamide Coenzyme Activity by a Polypeptide Derived from the Cell Wall of Lactobacillus leichmannii

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