Experimental vasospasm evaluated by Fourier waveform analysis

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概要

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• To clarify the significance of findings obtained by transcranial Doppler sonography (TCD) on vasospasm following subarachnoid hemorrhage, TCD monitoring was evaluated in an experimental model of vasospasm. The model consisted of mechanically stenosed arteries created by placing clips on the aorta and the femoral ar-teries in anesthetized rabbits. Flow velocity (FV) and Fourier's transformed pulsatility index (FPI<SUB>1-10</SUB>=each amplitude/mean FV) of 10 harmonics were assessed with two types of stenosis: (1) proximal stenosis by proximal clipping and (2) peripheral stenosis by distal clipping.<BR>Result: (1) proximal stenosis: at the stenotic region, FV, FPI<SUB>1</SUB>and some parts of FPI<SUB>2-10</SUB>were increased in accordance with an increase in stenosis with decreased flow volume. At the poststenotic resion, lower FV and higher FPI<SUB>1, 2-10</SUB>were observed in comparison with the stenotic region. (2) peripheral stenosis: FV and FPI<SUB>1</SUB>decreased with partial increase of FPI<SUB>2-10</SUB>were observed in accordance with an increase in stenosis and a decrease in flow volume.<BR>Conclusion: Fourier waveform analysis is useful in assessing a significant decrease in flow volume, and ap-pearance of ischemia due to vasospasm after subarachnoid hemorrhage.

• 日本脳神経超音波学会の論文

著者

• 冨田 泰彦

  杏林大学医学教育

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